As I study skin biology and acne pathology, one question that often arises is why some individuals barely experience acne throughout their lives. While some people struggle with acne lesions from adolescence into adulthood, others have skin that remains stable despite exposure to hormonal factors, environmental stressors, and lifestyle changes. From a cellular dermatology perspective,…

In clinical dermatology, hormonal acne is often misunderstood as simply a “greasy skin” problem or a normal hormonal imbalance. However, when I examine this condition from the perspective of cell biology and epidermal kinetics, it becomes clear that what we see on the skin surface is only the latest manifestation of a much more complex…

1. The Biological Disruption (The Clinical Problem) The onset of puberty marks a profound shift in the Endocrine-Dermal Axis, primarily driven by the systemic elevation of androgens, specifically Dehydroepiandrosterone Sulfate (DHEA-S) and Dihydrotestosterone (DHT). At the cellular level, these hormones act as high-affinity ligands for androgen receptors located within the Sebocytes and Keratinocytes of the…

1. The Biological Disruption (The Clinical Problem) Acne vulgaris is not merely a superficial accumulation of sebum or a cosmetic concern. It is a multifactorial inflammatory dermatosis involving dysregulation of the pilosebaceous unit, aberrant keratinocyte differentiation, and microbial colonization dominated by Cutibacterium acnes (formerly Propionibacterium acnes). The condition emerges through a coordinated biochemical cascade affecting…

Pernah tak korang rasa geram gila, dah jaga makan, dah cuci muka 3 kali sehari, tapi jerawat batu yang besar-besar tetap naik kat tempat sama? Pastu orang sekeliling pulak senang-senang cakap, “Kau tak cuci muka bersih kot ni.” Sumpah rasa nak marah, kan? Padahal korang dah try macam-macam produk “deep cleanse” sampai muka rasa tegang gila. Sebenarnya,…

Hi , today i would like to share one of the basic causes Acne. So, acne begins inside a microscopic structure called the pilosebaceous unit, which consists of a hair follicle and its attached sebaceous gland. At the cellular level, acne forms when dead skin cells fail to shed properly and mix with excess sebum.…

Pernah tak korang pakai produk baru, lepas tu naik jerawat pasir atau bintik merah gila-gila? Bila tanya seller atau tengok iklan, dorang kata: “Oh, tu tengah purging tu sis… dia tengah cuci kotoran dari dalam.” Korang pun sabar la pakai sampai sebulan, tapi makin lama muka makin pedih, merah, dan jerawat makin meriah sampai ke tempat yang…

Differential Diagnosis of Acclimatization “Purging” vs. Iatrogenic Acneiform Eruptions 1. The Biological Disruption (The Clinical Problem) Did you know , the phenomenon colloquially termed “purging” is clinically identified as an Accelerated Desquamation Cycle. This occurs when specific retinoids or hydroxy acids penetrate the Stratum Spinosum to upregulate keratinocyte proliferation. This biochemical shift forces pre-existing sub-clinical…

MUKA KERING MACAM PADANG PASIR? Wey, korang sebenarnya kena tipu dengan brand kayangan! 💸🌵 Pernah tak korang labur sampai ratusan ringgit beli luxury cream yang bau dia wangi gila, tekstur macam sutera, tapi bila bangun pagi… muka tetap rasa kering, kusam, dan barai? Lepas tu korang pelik, “Takkan krim RM300 kalah dengan tin biru RM10?” Sebenarnya, dalam lab, kita…